Non-Surgical Aesthetic Procedures


Although there were studies using different strains of botulinum toxin in the 1800s, the breakthrough in the use of botulinum toxin in aesthetics only became widespread in the 1970s.

It all started when Alan B. Scott, an ophthalmologist, obtained permission from the U.S. Food and Drug Administration (FDA) in 1978 to use botulinum toxin A for the treatment of strabismus. A pharmaceutical company in the United States obtained FDA approval for the use of botulinum toxin A under the trade name Oculinum in 1989 for the treatment of strabismus, blepharospasm, and hemifacial spasm. Two years later, the name was changed to Botox.

By 1992, when Canadian ophthalmologist Jean Carruthers applied blepharospasm treatment to a patient and noticed that the lines between the eyebrows disappeared, and Jean informed her husband, dermatologist Alastair, about this, the use of botulinum toxin for the treatment of wrinkles was ignited. After studies, the FDA approved it for glabellar (between the eyebrows) use in 2002. Subsequently, FDA approvals were obtained for axillary hyperhidrosis in 2004, chronic migraine and upper lip spasticity in 2010, and crow’s feet lines in 2013.

Botulinum toxin is produced by the bacterium Clostridium botulinum. Serologically, there are 8 different types. The most potent of these is type A (BoNTA).

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How does Botox work?

Normally, there is a substance called acetylcholine that facilitates transmission in nerve endings. This toxin stops the transmission between nerves and muscles by blocking the release of this substance. As a result, the muscle cannot contract. This effect is temporary. The effect generally starts in 72 hours, or 3 days, and the highest effect is seen within 2-3 weeks. The effect lasts for approximately 4 months.Resistance to Botox can develop. Antibody development causing this resistance is observed in 3-10% of cases. The probability of resistance increases in the following cases, so care should be taken:
  • When a very high dose is administered
  • When frequent and low doses are administered
  • When injections are administered at intervals of less than 3 months (administration between 3 weeks and 2.5 months is not recommended)
When is the application of botulinum toxin not recommended?
  • Those who are sensitive to any of the product components
  • Those with diseases such as Myasthenia Gravis, Eaton Lambert syndrome
  • Pregnancy
  • Breastfeeding

Botulinum Toxin A preparations in use worldwide

  • DYSPORT: Abobotulinumtoxin A (Ipsen, Speywood) —– Licensed in Turkey
  • BOTOX: Onabotulinumtoxin A (Allergan) —————– Licensed in Turkey
  • XEOMIN: Incobotulinumtoxin A (Merz)
  • NABOTA: Onabotulinumtoxin A (Daewoong)
  • BOTULAX: Onabotulinumtoxin A (Hugel)
  • HENGLI: Lanbotulinumtoxin A
  • LANTOX: Lanbotulinumtoxin A (Hugh)
  • PROSIGNE: Lanbotulinumtoxin A (Hugh)
  • LANZOX: Lanbotulinumtoxin A (Hugh)
  • REDUX: Lanbotulinumtoxin A
  • LIFTOX: Lanbotulinumtoxin A

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